Obesity Mutations Detection Kit with Next Generation Sequence Analysis
Obesity is now the most important public health problem in the world, causing significant problems both in the individual and social sense. While environmental effects and multifactorial inheritance are responsible for most cases of obesity, multiple forms of monogenic obesity have been reported.
In the majority of the monogenic obesity cases, molecular defects are detected in genes in the leptin-melanocortin signalling pathways. Biallelic mutations in the LEP, LEPR, PCSK1, and POMC genes, monoallelic mutations in the BDNF, MC4R, SIM1, and NTRK2 genes cause monogenic obesity.